18/07/2003

Depression lies in our DNA, scientists claim in new study

Scientists have claimed that depression could lie in our DNA, after a study is published suggesting that people with a specific version of a gene are afforded greater protection against the illness.

The gene – known as 5-TTT – is involved in the regulation of serotonin, a chemical which assists communication between brain cells. The gene comes in two versions, known as long and short, and everyone inherits two copies of the gene.

Researchers followed a group of 847 people from New Zealand over the first thirty years of their life, identifying what versions of the gene they possessed and recording what stressful events the individuals experienced and their subsequent reactions to those events.

Of the 265 people who inherited two short versions of the gene, 43% of them developed symptoms of depression following stressful events, while only 17% of those possessing two long copies of the gene reported being affected by the illness.

Researchers have suggested that the study provides a basis for the development of a genetic test for depression - which could see those with a genetic susceptibility targeted with medication or therapy as a preventative measure.

Marjorie Wallace, Chief Executive of mental health charity, SANE, said: "What this study shows is the importance of finding who may be particularly susceptible to the damaging combination of genetic vulnerability to depression and stressful life events, so that depressive breakdown might eventually be prevented."

(CL)


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